At 0005 hours, Box 37-4 sent Company 37 (Rescue), Engines 32 (Progress), 35 (Linglestown), 38 (Middle Paxton), Truck 35 (Linglestown), and Air 30 (Penbrook) to 1409 Regency Circle for a structure fire. Chief 84 went enroute, advised of a neighbor caller stating fire from the roof, and unknown if the occupants are out. PD on the scene reporting 2nd floor fully involved and Chief 84 arrived shortly after confirming the report with possible entrapment. A 1st alarm assignment brought Rescue 35 (Linglestown) and Squad 20 (Northeast) to the scene. Companies stretched multiple lines on a 2.5 story, single-family, dwelling knocking down the bulk of the fire in about 15 minutes. All searches negative and the fire was placed under control at 0040 hours.