At 0443, Box 302, 2444 Canby St, reported house on fire. Company 30 (Penbrook), Engines 31 (Edgemont), 32-1 (Progress), Wagon 4 (Harrisburg), Truck 32 (Progress), Tower 1 (Harrisburg), Rescues 40 (Paxtang), 44 (Lawnton). Caller advised 2nd floor on fire, PD on scene reporting working fire. Engine 32 on scene 2.5 story, duplex, smoke showing 2nd floor/attic side A, fire showing 2nd floor side D. Engine 30 picked up Engine 32’s line, Harrisburg Captain 2 (Wise) assumed command. Tower 1 & set up on side A. Captain 2 reported significant fire on the 2nd & 3rd floor rear of the building with two lines in service, searches underway. Chief 30 arrived and assumed command. First alarm assignment requested. Bulk of fire knocked on 2nd floor in about 15 minutes, interior crews opening up, and primary on Division 2 negative. 2 firefighters injured.