At 0503 hours, Box 1-3 sent companies to Reel and Seneca Streets for a reported house fire in the Uptown neighborhood. Dauphin County Communications advised of multiple calls, fire spreading to other houses, and PD reporting fully involved. Chief 4 (Miller) requested the first alarm enroute. Tower 2 on location with a fully involved structure. Chief 4 had 3 units off in the rear, requested the second alarm at 0509. Heavy fire in a 3 story, brick, stand-alone dwelling with extension to a 2.5 story, wood frame, duplex. Wagon 4 laid in from 6th & Curtain Streets and set up deck gun operations in the rear. A step gun was set up on side B along with numerous other attack lines for the fire building and exposures. Tower 2 set up on side A and flowed water into the fire building at 533 Seneca Street. Exterior operations on the fire building and interior attack on 531 and 529 Seneca St. The fire was placed under control in about 1 hour. Companies on the scene, Box Alarm: Wagon 3, Squad 8, Towers 1, 2, Chief 4. 1st Alarm: Wagon 4, Rescue 69, Air 13, Chief 1. 2nd alarm: Engines 30, 37-1, Trucks 32, 50, Rescue 44. Harrisburg Engine 2 with recall members. 3rd alarm: Engines 3-13, 40, Trucks 34, 10.