Shortly after 0730 hours Dauphin Box 302 sent companies to 2433 Canby Street in the Borough of Penbrook for smoke from a structure. Harrisburg Tower 1 reported a smoke column responding in from Walnut Street. Chief 30 on location with a working fire on the third floor of a multi-family, wood frame, dwelling. Reports of all occupants being out were sketchy so crews went in service with interior attack and search/rescue operations. All searches were quickly cleared as being negative. Multiple lines were stretched to the top floors as members from Tower 1 and Truck 32 (Progress) opened up the roof. Command 30 requested the first alarm as heavy smoke and fire eminated from the structure. Aggressive interior work and vertical ventilation allowed firefighters to quickly knock down the bulk of the fire and check for hot spots. No injuries were reported and the fire left several occupants homeless.